This study aimed to determine the role of cognitive schemata in the prediction of adjustment in female students with symptoms of Oppositional Defiant Disorder. In this descriptive-correlational study, the population consisted of all female high school students with symptoms of Oppositional Defiant Disorder in the city of Ardabil (district one). The sample was a group of 180 female high school students with high scores on the Oppositional Defiant Disorder Checklist. Data were collected through the Young Schema Questionnaire- Short Form, the Adjustment Inventory for School Students and the Oppositional Defiant Disorder Checklist and analyzed via Pearson correlation coefficient and multiple regression analysis. The results indicated a significant relationship between cognitive schemata and the adjustment level of students with Oppositional Defiant Disorder (r=-0.23, p>0.001). Furthermore, the results of multiple regression analysis showed that %7.7 of variances in the students’ adjustment level could be predicted by their cognitive schemata indicating the low predictive power of cognitive schemata for the determination of the adjustment level of students with Oppositional Defiant Disorder.